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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity

Fig. 1

5xFAD serum-derived exosomes are enriched with ceramide and associated with GFAP. a-b Cluster analysis of wild type (WT) and 5xFAD serum-derived exosomes after Nano Particle Tracking analysis showing a population of larger exosomes in 5xFAD serum. N = 3 (c) Immunoblot of exosome markers CD9, CD63, CD81, flotillin-1, and flotillin-2, demonstrating higher amounts of GFAP in 5xFAD exosomes compared to WT exosomes. d-e Ceramide species profile determined using LC-MS/MS of WT and 5xFAD serum-derived exosomes and normalized to lipid phosphate content (d) and to exosome count (e) Asterisks denote significance (p < 0.05) after Two-way ANOVA followed by Bonferroni correction (N = 3)

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