Table 1 Univariable analysis comparing clinical and radiographic variables between atypical DIPG (aDIPG) without an H3 K27M mutation and typical DIPG (tDIPG)
| Characteristic | aDIPG without K27M mutation (n = 21) | tDIPG (n = 100) | P |
|---|---|---|---|
| Clinical | |||
| Age @ diagnosis (years), median (IQR) | 4.8 (2.5,7.6) | 6.2 (4.2,8.4) | 0.09 |
| Sex, no. (%) | |||
| Male | 12 (57%) | 45 (45%) | 0.34 |
| Female | 9 (43%) | 55 (55%) | |
| Race, no. (%) | |||
| Black | 5 (24%) | 18 (18%) | 0.31 |
| White | 12 (57%) | 72 (72%) | |
| Other | 4 (19%) | 10 (10%) | |
| Symptom duration (mo), median (IQR) | 1.0 (0.5,6.0) | 1.0 (0.5,2.0) | 0.52 |
| Cranial nerve palsy, no. (%) | |||
| Yes | 17 (81%) | 95 (95%) | 0.05 |
| No | 4 (19%) | 5 (5%) | |
| Pyramidal tract symptoms, no. (%) | |||
| Yes | 8 (38%) | 70 (70%) | 0.01 |
| No | 13 (62%) | 30 (30%) | |
| Cerebellar symptoms, no. (%) | |||
| Yes | 13 (62%) | 78 (78%) | 0.16 |
| No | 8 (38%) | 22 (22%) | |
| CSF diversion, no. (%) | |||
| Yes | 3 (14%) | 17 (17%) | 1.00 |
| No | 18 (86%) | 83 (83%) | |
| Systemic therapy @ diagnosis, no. (%) | |||
| Yes No | 11 (52%) 10 (48%) | 92 (92%) 8 (8%) | <.0001 |
| Radiologic | |||
| Tumor size (mL), median (IQR) | 20.5 (16.0,37.5) | 38.8 (27.9,51.4) | 0.002 |
| Ring enhancement @ diagnosis, no. (%) | |||
| Yes | 1 (5%) | 42 (42%) | 0.001 |
| No | 20 (95%) | 58 (58%) | |
| Growth in mesencephalon, no. (%) | |||
| Yes | 6 (29%) | 86 (86%) | <.0001 |
| No | 15 (71%) | 14 (14%) | |
| Growth in medulla, no. (%) | |||
| Yes | 13 (62%) | 74 (74%) | 0.29 |
| No | 8 (38%) | 26 (26%) | |
| Growth in middle cerebellar peduncle, no. (%) | |||
| Yes | 10 (48%) | 67 (67%) | 0.13 |
| No | 11 (52%) | 33 (33%) | |
| Tumor margin, no. (%) | |||
| Ill-defined | 14 (67%) | 71 (71%) | 0.79 |
| Well-defined | 7 (33%) | 29 (29%) | |
| Eccentricity within pons, no. (%) | |||
| Yes | 9 (43%) | 20 (20%) | 0.05 |
| No | 12 (57%) | 80 (80%) | |
| Extrapontine extension, no. (%) | |||
| Yes | 7 (33%) | 11 (11%) | 0.02 |
| No | 14 (67%) | 89 (89%) | |