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Table 1 Univariable analysis comparing clinical and radiographic variables between atypical DIPG (aDIPG) without an H3 K27M mutation and typical DIPG (tDIPG)

From: Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG

CharacteristicaDIPG without K27M mutation (n = 21)tDIPG (n = 100)P
Clinical
Age @ diagnosis (years), median (IQR)4.8 (2.5,7.6)6.2 (4.2,8.4)0.09
Sex, no. (%)
 Male12 (57%)45 (45%)0.34
 Female9 (43%)55 (55%) 
Race, no. (%)
 Black5 (24%)18 (18%)0.31
 White12 (57%)72 (72%) 
 Other4 (19%)10 (10%) 
Symptom duration (mo), median (IQR)1.0 (0.5,6.0)1.0 (0.5,2.0)0.52
Cranial nerve palsy, no. (%)
Yes17 (81%)95 (95%)0.05
No4 (19%)5 (5%) 
Pyramidal tract symptoms, no. (%)
Yes8 (38%)70 (70%)0.01
No13 (62%)30 (30%) 
Cerebellar symptoms, no. (%)
 Yes13 (62%)78 (78%)0.16
 No8 (38%)22 (22%) 
CSF diversion, no. (%)
 Yes3 (14%)17 (17%)1.00
 No18 (86%)83 (83%) 
Systemic therapy @ diagnosis, no. (%)
Yes
No
11 (52%)
10 (48%)
92 (92%)
8 (8%)
<.0001
Radiologic
Tumor size (mL), median (IQR)20.5 (16.0,37.5)38.8 (27.9,51.4)0.002
Ring enhancement @ diagnosis, no. (%)
Yes1 (5%)42 (42%)0.001
No20 (95%)58 (58%) 
Growth in mesencephalon, no. (%)
Yes6 (29%)86 (86%)<.0001
No15 (71%)14 (14%) 
Growth in medulla, no. (%)
 Yes13 (62%)74 (74%)0.29
 No8 (38%)26 (26%) 
Growth in middle cerebellar peduncle, no. (%)
 Yes10 (48%)67 (67%)0.13
 No11 (52%)33 (33%) 
Tumor margin, no. (%)
 Ill-defined14 (67%)71 (71%)0.79
 Well-defined7 (33%)29 (29%) 
Eccentricity within pons, no. (%)
Yes9 (43%)20 (20%)0.05
No12 (57%)80 (80%) 
Extrapontine extension, no. (%)
Yes7 (33%)11 (11%)0.02
No14 (67%)89 (89%) 
  1. Abbreviations: IQR interquartile range, WHO World Health Organization