Fig. 5

Overall survival (OS) of the atypical DIPG (aDIPG) cohort (a) compared with that of a contemporary typical DIPG (tDIPG) cohort. There was no significant difference in OS among the subgroups of patients with aDIPG, whereas the OS of patients with tDIPG was significantly worse (P < 0.00001). Histone H3 K27M mutation status was the major determinant of OS in diffuse aDIPG (b). There was no significant difference in OS between patients with H3 K27M–mutant aDIPG and tDIPG