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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Foetal onset of EIF2B related disorder in two siblings: cerebellar hypoplasia with absent Bergmann glia and severe hypomyelination

Fig. 1

Main macroscopic and histological findings of EIF2B5 mutated foetal brain aged 32 WG. a External view of the right hemisphere of the second foetus showing almost closed Sylvian fissure (arrow), absent postcentral gyrus whereas the central fissure is present (arrowhead) and dysmorphic superior temporal gyrus (asterisk) with poor secondary sulcation. b compared with an age-matched control brain where the Sylvian fissure is still open (arrow), with all primary and secondary sulci and gyri already formed, in particular the superior temporal sulcus (asterisk). c With on coronal section passing through the diencephalon where several small-sized periventricular pseudo-cysts are observed (black arrow) whereas the corpus callosum is normal (white arrow). d Histology of the cerebellar cortex displaying an abnormal five-layered immature cortex with abnormal persistence of the lamina dissecans (transient layer IV, arrow) corresponding to a developmental stage of 24 WG [OM × 100]. e Luxol- phloxin stain of the medulla oblongata just above the decussation of pyramids (asterisk) displaying no myelin in the second foetus [OM × 16]. f Compared with an age matched control, where all fascicles are myelinated, except corticospinal tracts (asterisk) which begin to be myelinated [OM × 16]. g Absent myelination around the poorly convoluted dentate nucleus and vacuolization of the cerebellar white matter inside the dentate nucleus (asterisk) [OM × 50]. h Compared with the control where the dentate nucleus is normally convoluted and surrounded by myelinated white matter [OM × 50]

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