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Table 1 List of cadaveric epilepsy cases with recorded clinical features. 21 cadaveric epilepsy cases with history of single or multiple events of seizures, accompanied with a table of clinical history obtained from the archives of Seattle Children’s Hospital Department of Pathology (2014–2019), are tabulated. The features analyzed included age of death, gender, post-mortem interval (PMI), presence or absence of GCD subtypes, clinical diagnoses like seizure interval (from seizure onset until death), evidence of malformation/anomaly in the central nervous system (CNS), and/or of other CNS (acquired forms of CNS injury such as hypoxic-ischemic encephalopathy (HIE), cerebral edema) and non-CNS conditions. GW, gestational weeks; TT, tram-track; DA, disaggregated; mo, months

From: Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures

CodeAge of death (GW)Corrected age of deathGenderPMISeizure (Y/N)Seizure intervalGCD (Y/N)Diagnoses
TTDACNS malformation/anomalyOther (CNS)Non-CNS conditions
SZ-1a7 days7 daysM12 hY< 24 hYYencephalopathy, seizuresProteus mirabilis septic shock, coagulopathy and acidosis, hypoxic respiratory failure
SZ-2a6 years6 yearsF10 hY6 years; intractableNNglobal developmental delay, chronic seizure disorder with static encephalopathyhypoplastic cerebellumrecurrent pulmonary infections
SZ-3a16 years16 yearsF22 hY13 yearsNYsevere congenital neuromuscular disorder, complex status epilepticussevere gliosis and neuronal lossacute bronchopneumonia, cardiac arrest
SZ-4b6 years6 yearsMnot knownY> 5 years; multiple episodes till death, intractableYYbrain overgrowth with polymicrogyria, diffused cortical dysplasia, AKT3 R465W mutation, possibly SUDEPgliosis, mild ventriculomegalycongenital diaphragmatic hernia, coagulopathy, defects in liver, spleen and kidney
SZ-5a3 years3 yearsM2 hY7 weeks; multiple episodes till death, intractableYNsubclinical status epilepticuscerebral edema, HIE, anoxic brain injury secondary to pulmonary arrestpulmonary arrest
SZ-6a2 days2 daysF21.5 hY2 days (possible seizures)YYcerebral edema, HIEacute chorioamnionitis with funisitis and three vessel umbilical vasculitis
SZ-7a4 days4 daysM38 hY< 24 hNYHIEsevere acidosis, cardiorespiratory failure, visceral anomalies
SZ-8a18mo18moM26 hY1–3 months of age; no further seizures post-treatment of phenobarbitalYYdevelopmental delay and seizure disorder (2q21.1 duplication)focal neuronal loss and gliosis in hippocampusabdominal distension, brady-cardiac arrest, acute pan-lobar pneumonia
SZ-9a2 years2 yearsM72 hY4 months; multiple episodes between first seizure and deathNNretinoblastoma with diffuse leptomeningeal spread and direct infiltration of brain and spinal cordpulmonary edema, congestive hepatomegaly
SZ-10a5 weeks (28GW)33GWF17.5 hY< 24 hYYmultiple seizure eventshemorrhage and necrosis secondary to dural venous thrombosis.necrotizing enterocolitis
SZ-11a12 years12 yearsF96 hY16 months; intractableNNcerebral edema, HIE and brain deathappendicitis
SZ-12a19 years19 yearsM216 hY14 years; intractableNNseizure disorderTrisomy 16p/monosomy 9p, respiratory distress syndrome, Pseudomonas pneumonia, cardiomegaly
SZ-13a7 weeks (32 4/7 GW)39 4/7 GWF14 hY6 weeks (possible seizures)NYepilepsy (focal apoptotic neurons within DG)severe pulmonary hypertension, veno-occlusive disease
SZ-14a8 years8 yearsF65 hY2 years (sleep EEG done)NNencephalomalacia, hydrocephalus, seizures, developmental delayunbalanced chromosomal translocation, congenital mitral valve stenosis, heart failure
SZ-15a7 weeks7 weeksF3 hY6 weeksNYhypotonia and episodic breathing progressing to seizureselevated CSF and plasma glycine levels
SZ-16a17 years17 yearsF96 hY5 daysNNgeneralized tonic-clonic seizure, brain herniationacute hemorrhage, edemaType 1 diabetes, oligoarticular juvenile arthritis, celiac disease
SZ-17a17 years17 yearsM64 hY~ 17 years; intractableNYspastic quadriplegia, epilepsy, static leukoencephalopathy, ventriculomegalywhite matter gliosisacute kidney injury, obstructive apnea, hypotonia
SZ-18a8 days8 daysM42 hY8 days
(onset at birth)
NNseizures (treated with antiepileptics)brain herniation, diffuse cerebral edemaornithine transcarbamylase deficiency, hyperammonemia, hepatosplenomegaly
SZ-19a3 years3 yearsF15.6 hY2.5 yearsNNsevere craniofacial malformations, seizure historyneurological injury, meningitis
SZ-20a4 years4 yearsM15.5 hY16 monthsNNseizures (no recurrence post-treatment with medications), global developmental delaysubacute diffuse CNS hemorrhagic necrosis with massive intraventricular blood clotmultiple chromosomal abnormalities and associated chronic health problems, atypical lymphoid hyperplasia, concerning primary or secondary immunodeficiency
SZ-21a9 years9 yearsM2 hY2 monthsNNrefractory status epilepticus secondary to febrile infection-related status epilepticus, multiple eventsdiffuse severe gliosis, patchy neuronal loss, dramatic loss of CA1 neurons
  1. a based on microscopic evaluation of archived hippocampal sections
  2. b case published in [3, 46]; unused right hemisphere was obtained from SCH morgue and pathological studies were done by RPK on the right hippocampus for the first time for this study