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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures

Fig. 2

Cadaveric hippocampi reveal the GCD spectrum in controls with no history of seizures. (a-d’) H&E staining of coronal hippocampal sections of control human cadavers, with no history of epilepsy or seizure, revealed the entire spectrum of GCD ranging from focal tram-track (TT) to disaggregated (DA) forms, as observed in some seizure cases. Often, TT and DA forms are seen at the same plane of section. Open arrowhead indicates inner granular zone proximal to hilus; arrowhead indicates outer granular zone distal to hilus. (e) Frequencies of GCD subtypes in seizure cases (11/21) were not significantly different from that in controls (50/126), as determined by two-way ANOVA, followed by Tukey post-hoc test (p > 0.9996). (f) Comparison of the maximum thickness of GC layer between control and seizure hippocampal samples, measured as shown in (h,i), revealed no significant differences in all DG subtypes – compact, TT, DA. But the maximum GC thicknesses of both TT and DA sets were significantly higher than the compact ones (p < 0.0001). (g) Ratios of inner or outer layer thickness to the total GC thickness, as demonstrated in (i), showed no significant difference between control and mutant, as well as within each group. Data are represented as 100% stacked columns (e), mean ± SEM (f) or mean ratio ± SEM (g) in scatter plots; two-way ANOVA followed by Tukey post-hoc test were performed. Differences were considered significant at p < 0.05; ns, not significant. Scalebars: 1 mm (a, b, c, d); 50 μm (a’, b’, c’, d’)

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