Table 1 Rodent TBI injury models. Controlled cortical impact (CCI), Fluid percussion injury (FPI), Penetrating ballistic brain injury (PBBI), and closed head injury (CHI) weight drop are the most commonly used injury methods
From: Biological links between traumatic brain injury and Parkinson’s disease
Model | Injury type | Preparatory surgery | Rodent |
|---|---|---|---|
Blast | Diffuse | None | |
CCI | Focal | Craniotomy | |
FPI | |||
Middle | Mixed | Craniotomy | Rat [102] |
Lateral | Mixed | Craniotomy | |
Repetitive | Diffuse | Craniotomy | Rat [34] |
PBBI | Focal | Cranial incision, burr hole | Rat [162] |
Weight drop | |||
Buchele | Diffuse | Cranial incision | Rat [16] |
Citron | Repetitive, diffuse | None | Mouse [133] |
Marmarou | Diffuse | Cranial incision, reflected periosteum | Rat [96] |
Maryland model | Diffuse | Infraorbital incisions, temporary implant | Rat [73] |
Pick | Diffuse | None | Mouse [169] |
Shohami | Focal | Cranial incision | |