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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Enhanced accumulation of N-terminally truncated Aβ with and without pyroglutamate-11 modification in parvalbumin-expressing GABAergic neurons in idiopathic and dup15q11.2-q13 autism

Fig. 9

Aβ-pE11 (R510) in a control, 8 years old, and dup-15 (10-year-old and 15-year-old). The immunoreaction is almost negligible in the control, while in dupl-15 numerous small profiles are present in the cytoplasm and nucleus. The reaction is in part localized in lysosomes, detected by the reaction for Cathepsin D (cath D), and is partially co-localized with the immunostainings with mAb 4G8 and mAb MOAB2. A significant fraction of the reactivity for Aβ-pE11 is visible in the nucleus. The scale bars show 20 μm

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