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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Enhanced accumulation of N-terminally truncated Aβ with and without pyroglutamate-11 modification in parvalbumin-expressing GABAergic neurons in idiopathic and dup15q11.2-q13 autism

Fig. 2

Prefrontal cortex lysates, pellets and supernatant from sequential centrifugations performed in samples from control and autism cortex samples. The contents of the Aβ40– (a, b) and Aβ42–immunoreactive peptides (c, d) were significantly higher in the autism than in the control cortex. The Aβ40 peptides in autism were detected as dimers and 18-24kD protein bands, the latter present mainly in pellet 1, containing larger subcellular structures. Aβ42 was detected mainly as 18-24kD and 32-34kD with a minor contribution of dimers and a 50-52kD protein band, all of which were more abundant in autism. Pellets 1 and 2 contained most of the Aβ42 complexes of molecular sizes 18-24kD and 32-34kD. The majority of the Aβ42 complexes of molecular sizes 32-34kD were detected in the soluble fraction (supernatant 3). The graphs (b, d) show average values from 3 experiments

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