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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Enhanced accumulation of N-terminally truncated Aβ with and without pyroglutamate-11 modification in parvalbumin-expressing GABAergic neurons in idiopathic and dup15q11.2-q13 autism

Fig. 1

Prefrontal cortex in 8-year-old control and 11-year-old autistic subjects immunostained with C-terminal APP-specific antibody R57 (red color), mAb 4G8 (green color) and nuclei counterstained blue with TOPRO-3i. The neurons in the control contain numerous R57 immunoreactive granules and very scanty reaction with mAb4G8. In autism R57 immunoreactive material in distinct neurons is either partially 4G8-positive or mostly 4G8-negative, while only a fraction of 4G8-positive granules is positive for C-terminal APP, as shown in the magnified image (autism-magn.)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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