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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia

Fig. 9

Inhibition of bilateral LHb by chemicogenetic intervention or Tacr3 overexpression reversed pT-ION-induced allodynia and anxiety-like behaviors. (a) Schematic diagram showing the virus injection sites in the LHb. The green areas and black dots represent virus injection sites. (b) Typical immunofluorescence staining showing the virus transfection location in the bilateral LHb. Green, EGFP; Blue, DAPI. (c) The primary mechanical allodynia (left panel), secondary mechanical allodynia (middle panel), and secondary cold allodynia (right panel) were improved by bilateral HM4Di-CNO application and by Tacr3 overexpression. *** p < 0.001 vs. the pT-ION+HM4Di + Saline group, # p < 0.05, ## p < 0.01 vs. the pT-ION+AAV-Tacr3-control group. (d) The decreases in percent of open-arm distance, time, and entries were completely reversed by bilateral HM4Di-CNO application and by Tacr3 overexpression. *** p < 0.001 vs. the pT-ION+HM4Di + Saline group; ## p < 0.01 vs. the pT-ION+AAV-Tacr3-control group. (e) The central distance, central time, and central/total distance were significantly increased by bilateral HM4Di-CNO application and by Tacr3 overexpression. *p < 0.05, ** p < 0.01 vs. the pT-ION+HM4Di + Saline group; ## p < 0.05, ### p < 0.01 vs. the pT-ION+AAV-Tacr3-control group

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