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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia

Fig. 8

The electrophysiological activity of LHb neurons was suppressed by Tacr3 overexpression. (a) The expression of p-CaMKII in the LHb was decreased after AAV-Tacr3-Ove injection and HM4Di-CNO administration. # p < 0.05, vs. control. (b) Typical current recorded by whole-cell patch clamp showing the suppression of both frequency and amplitude of sEPSCs by Tacr3 overexpression. (c) Corresponding cumulative distribution and quantification of sEPSC amplitudes. (d) Corresponding cumulative distribution and quantification of sEPSC frequencies. *p < 0.05, **p < 0.01 vs. the pT-ION+AAV-Tacr3-control group, n = 10 neurons from 4 to 6 mice per group

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