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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia

Fig. 7

Tacr3 overexpression in the unilateral LHb improved the pT-ION-induced anxiety-like behaviors, but not the allodynia. (a) The virus injection sites in the LHb. The green area and black dots represent the virus injection sites. (b) Typical immunofluorescence staining for AAV-Tacr3-Ove virus (EGFP, green) and DAPI (blue). (c) The expression of Tacr3 was significantly increased in LHb neurons. # p < 0.05 vs. the sham group; ** p < 0.01 vs. the pT-ION+AAV-Tacr3-control group. (d) The primary mechanical allodynia (left panel), secondary mechanical allodynia (middle panel), and secondary cold allodynia (right panel) were not changed by Tacr3 overexpression. ### p < 0.001 vs. the sham group. (e) The decrease in percent of the open-arm distance, time, and entries in the EPM were completely reversed by Tacr3 overexpression. # p < 0.05 vs. the sham group; *** p < 0.001 vs. the pT-ION+AAV-Tacr3-control group. (f) The central distance, central time, and central/total distance were significantly increased after Tacr3 overexpression. # p < 0.05, ## p < 0.01, ### p < 0.001 vs. the sham group; *p < 0.05, ** p < 0.01 vs. the pT-ION+AAV-Tacr3 control group

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