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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Characterising cellular and molecular features of human peripheral nerve degeneration

Fig. 2

Immunohistochemical detection of neurons in healthy and denervated human nerves. a– c represent nerve cross sections stained for neurofilament (brown) with haematoxylin and eosin stain. The black arrow in the micrograph represents positive neurofilament staining. In d and e the black dotted line represents the mean number of axons detected in healthy nerve samples (case number 4 and 8). The x-axis is Log (denervation time in days). a Healthy sural nerve. b Biceps branch of the musculocutaneous nerve denervated for 30 days. c Axillary nerve denervated for 294 days with deteriorated morphology. d A scatter plot to represent Log (axon count/mm2) against denervation time. e Nonparametric smoothing linear regression of the Log (axon count/mm2) against denervation time. Case numbers are attached to each data point for reference to Table 1 with descriptors of whether the sample was collected proximally or distally: m1 - Proximal part of the denervated stump of the biceps branch of musculocutaneous nerve. m2 - Distal part of the denervated stump of the biceps branch of musculocutaneous nerve. b1 - Proximal section of the denervated stump of the brachialis branch of musculocutaneous nerve. s1 - Denervated stump of suprascapular nerve. sa1 - Proximal section of the denervated stump of the spinal accessory nerve. sa2 - Distal section of the denervated stump of the spinal accessory nerve

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