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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Abnormal mitosis in reactive astrocytes

Fig. 9

Levels of GFAP and alphaB-crystallin immunoreactivities correlate with the appearance of abnormal mitoses. a Lagging chromosomes (arrow) are separated from the main group by cytoplasm with high levels of GFAP immunoreactivity. a1 – single optical slice. a1’- enlarged image of chromosomes in a1. For an animated 3D reconstruction of (a) see Additional file 9A. b Significant positive correlation between levels of GFAP immunoreactivity and numbers of arrested mitoses. Regression analysis, R = 0.810. c, d In areas of severe astrogliosis (c) there are astrocytes with arrested mitosis (arrows); in mild astrogliosis (d) at a distance from the damaged area arrested mitosis are not observed. e) alphaB-crystallin (Crystallin) is located around chromosomes in arrested mitosis. Right lower inset shows position of chromosomes. All images were obtained with confocal microscope. Scale bars: a = 20 μm,  c,d = 80 μm,  = 18 μm

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