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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Abnormal mitosis in reactive astrocytes

Fig. 8

Aurora B in mitotic astrocytes. a-c Aurora B immunoreactivity in normal mitoses, in prophase (a), metaphase (b), and telophase (c). Note that in prophase and metaphase Aurora B is found in focal areas in chromosomes (kinetochores). d Typical pattern of Aurora B immunoreactivity in multinucleated astrocytes. e Double immunostaining for Aurora B and BUB3. e1 – enlarged upper boxed area with arrested mitosis. Note that BUB3 immunoreactivity is minimal, whereas Aurora B is preserved in kinetochores. e2- enlarged lower boxed area with chromosomes congressed in metaphase plate. Note that both Aurora B and BUB3 are colocalized at kinetochores in congressed chromosomes (e2) but in arrested mitosis (e1) where BUB3 (arrows) but not Aurora B is found not connected with chromosomes. All images were obtained with confocal microscope. Scale bars:  a-d = 15 μm, e = 75 μm

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