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Table 1 Clinical and Tumor characteristics

From: Simultaneous detection of EGFR amplification and EGFRvIII variant using digital PCR-based method in glioblastoma

Characteristics Entire cohort
N = 62
Exploratory cohort
N = 19
Validation cohort
N = 43
Age (years), mean [min. – max.] 56.9 [21–76]55.5 [28–76]57.7 [21–72]
SexFemale28 (45%)7 (37%)21 (49%)
Male34 (55%)12 (63%)22 (51%)
SurgeryBiopsy25 (40%)8 (42%)17 (40%)
Resection37 (60%)11 (58%)26 (60%)
Glioblastoma IDH wild type 59 (95%)18 (95%)41 (95%)
Giant cell glioblastoma1 (2%)1 (5%)0
Gliosarcoma2 (3%)02 (5%)
Glioblastoma IDH mutant 3 (5%)1 (5%)2 (5%)
EGFR amplification by FISH 27 (43%)8 (42%)19 (44%)
MGMTp methylationNon-methylated37 (60%)13 (68%)24 (56%)
Methylated17 (27%)6 (32%)11 (26%)
Unknown8 (13%)08 (18%)
TERTp mutationC228T41 (66%)14 (74%)27 (63%)
C250T14 (23%)4 (21%)10 (23%)
Wild-type7 (11%)1 (5%)6 (14%)