Table 2 Visual analyses of mitochondrial respiratory chain staining
Protein | Group | Number of Neurons | % Deficient neurons | |||||
|---|---|---|---|---|---|---|---|---|
Mean (95% CI) | ANOVA Welch (P =) | η2 | Group comparisons | GH (P =) | ||||
CA4/CA3 | VDAC1 | Ctrl | 1242 | 0 (0,0) | 0.621 | – | Ctrl vs VV2 | – |
VV2 | 2404 | 0.06 (−0.07,0.19) | Ctrl vs MM1 | – | ||||
MM1 | 2411 | 0.08 (−0.04,0.19) | MM1 vs VV2 | – | ||||
NDUFB8 | Ctrl | 1442 | 5.76 (2.72, 8.80) | 0.006 | 0.310 | Ctrl vs VV2 | 0.302 | |
VV2 | 2499 | 20.17 (− 0.32, 40.66) | Ctrl vs MM1 | 0.010 | ||||
MM1 | 2085 | 51.45 (24.51, 78.39) | MM1 vs VV2 | 0.122 | ||||
SDHA | Ctrl | 1194 | 0.61 (−0.30, 1.51) | 0.019 | 0.195 | Ctrl vs VV2 | 0.075 | |
VV2 | 2052 | 5.58 (1.17, 9.99) | Ctrl vs MM1 | 0.097 | ||||
MM1 | 1878 | 15.55 (1.27, 29.83) | MM1 vs VV2 | 0.325 | ||||
UQCRC2 | Ctrl | 1381 | 0.26 (−0.07, 0.59) | 0.119 | – | Ctrl vs VV2 | – | |
VV2 | 1675 | 0.54 (−0.21, 1.29) | Ctrl vs MM1 | – | ||||
MM1 | 1913 | 9.28 (−0.14, 18.71) | MM1 vs VV2 | – | ||||
MTCO1 | Ctrl | 1282 | 2.18 (0.71, 3.64) | 0.040 | 0.255 | Ctrl vs VV2 | 0.373 | |
VV2 | 2263 | 6.99 (−0.61, 14.58) | Ctrl vs MM1 | 0.062 | ||||
MM1 | 2000 | 27.52 (5.92, 49.12) | MM1 vs VV2 | 0.151 | ||||
ATP5A | Ctrl | 1252 | 0.37 (−0.57, 1.30) | 0.003 | 0.331 | Ctrl vs VV2 | 0.019 | |
VV2 | 1803 | 4.01 (1.62, 6.40) | Ctrl vs MM1 | 0.034 | ||||
MM1 | 1554 | 20.96 (5.49,35.48) | MM1 vs VV2 | 0.082 | ||||
Temporal cortex | VDAC1 | Ctrl | 1942 | 2.71 (−0.05, 5.46) | 0.542 | – | Ctrl vs VV2 | – |
VV2 | 2876 | 6.10 (−0.09, 12.29) | Ctrl vs MM1 | – | ||||
MM1 | 2784 | 3.26 (−1.38, 7.89) | MM1 vs VV2 | – | ||||
NDUFB8 | Ctrl | 1275 | 6.82 (−0.31, 13.96) | 0.001 | 0.603 | Ctrl vs VV2 | 0.116 | |
VV2 | 2116 | 27.68 (7.12, 48.25) | Ctrl vs MM1 | < 0.001 | ||||
MM1 | 1633 | 67.50 (51.98, 83.01) | MM1 vs VV2 | 0.008 | ||||
SDHA | Ctrl | 1171 | 0.54 (−0.18, 1.25) | 0.001 | 0.547 | Ctrl vs VV2 | 0.071 | |
VV2 | 1822 | 16.62 (2.47, 30.77) | Ctrl vs MM1 | 0.001 | ||||
MM1 | 1107 | 55.95 (34.93, 76.97) | MM1 vs VV2 | 0.008 | ||||
UQCRC2 | Ctrl | 1461 | 0.97 (−0.42, 2.36) | 0.003 | 0.492 | Ctrl vs VV2 | 0.278 | |
VV2 | 1666 | 5.38 (−0.60, 11.37) | Ctrl vs MM1 | 0.005 | ||||
MM1 | 975 | 35.39 (17.23, 53.56) | MM1 vs VV2 | 0.012 | ||||
MTCO1 | Ctrl | 1237 | 6.31 (−1.12, 13.75) | 0.001 | 0.727 | Ctrl vs VV2 | 0.179 | |
VV2 | 1895 | 14.18 (7.38, 20.97) | Ctrl vs MM1 | < 0.001 | ||||
MM1 | 1515 | 58.60 (41.42, 75.77) | MM1 vs VV2 | 0.001 | ||||
ATP5A | Ctrl | 1758 | 1.78 (−1.57, 5.13) | 0.003 | 0.404 | Ctrl vs VV2 | 0.162 | |
VV2 | 2034 | 16.92 (0.14, 33.70) | Ctrl vs MM1 | 0.007 | ||||
MM1 | 1127 | 50.57 (24.19, 76.94) | MM1 vs VV2 | 0.066 | ||||