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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease

Fig. 1

Neuropathological evaluation of sCJD tissue. Representative examples of the neuropathological evaluation of our samples. (A-B) Gliosis (a) and vacuolation (b) were scored based on hematoxylin and eosin stainings on a scale from no gliosis/vacuolation (0), to slight (1), moderate (2) and severe (3) state. Scalebar: 50 μm. (c) Representative examples of PrPsc-immunoreactivity in a negative control (0), and individuals with MM1 type sCJD showing slight (1), moderate (2) and prominent (3) diffuse/synaptic immunoreactivity. Scale bar: 100 μm. (d-e) Neurons stained with mitochondrial markers were dichotomized and labeled as positive (d) or deficient (negative and intermediate staining) (e)

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