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Table 3 Demographics and clinical characteristics in 116 donors with LP categorized according to MDS-PD criteria 19

From: Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series

 

Established PD donors with LP

Not PD or probable PD donors with LP

N

71

45

Sex M, n (%)

38 (54%)

33 (73%)*

Age at onset y, mean ± SD (range)

60 ± 11 (32–78)

63 ± 12 (40–84)

Age at death y, mean ± SD (range)

77 ± 8 (56–90)

76 ± 9 (56–90)

Disease duration y, mean ± SD (range)

17 ± 8 (4–42)

13 ± 6 (3–31)**

Dementia, n (%)

37 (52%)

24 (53%)

Duration of dementia y, mean ± SD (range)

4 ± 3 (0–12)

4 ± 2 (0–7)

Visual hallucinations, n/N (%)

48/61 (79%)

25/36 (69%)

Rest tremor, n/N (%)

62/70 (89%)

31/42 (74%)*

Clear response to dopaminergic therapy, n/N (%)

68/71 (96%)

26/41 (63%)***

Positive family history of parkinsonism, n/N (%)

13/34 (38%)

14/26 (54%)

APOE ε4 alleles, n/N (%)

 0

28/45 (62%)

16/24 (67%)

 1

15/45 (33%)

8/24 (33%)

 2

2/45 (4%)

0/24 (0%)

  1. P-values are shown for comparisons between ‘established PD’ and ‘not PD’ combined with ‘probable PD’ donors with LP using t-tests for continuous variables and chi-square tests for categorical variables. * p < 0.05; ** p < 0.01; *** p < 0.001