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Table 3 Demographics and clinical characteristics in 116 donors with LP categorized according to MDS-PD criteria 19

From: Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series

 Established PD donors with LPNot PD or probable PD donors with LP
N7145
Sex M, n (%)38 (54%)33 (73%)*
Age at onset y, mean ± SD (range)60 ± 11 (32–78)63 ± 12 (40–84)
Age at death y, mean ± SD (range)77 ± 8 (56–90)76 ± 9 (56–90)
Disease duration y, mean ± SD (range)17 ± 8 (4–42)13 ± 6 (3–31)**
Dementia, n (%)37 (52%)24 (53%)
Duration of dementia y, mean ± SD (range)4 ± 3 (0–12)4 ± 2 (0–7)
Visual hallucinations, n/N (%)48/61 (79%)25/36 (69%)
Rest tremor, n/N (%)62/70 (89%)31/42 (74%)*
Clear response to dopaminergic therapy, n/N (%)68/71 (96%)26/41 (63%)***
Positive family history of parkinsonism, n/N (%)13/34 (38%)14/26 (54%)
APOE ε4 alleles, n/N (%)
 028/45 (62%)16/24 (67%)
 115/45 (33%)8/24 (33%)
 22/45 (4%)0/24 (0%)
  1. P-values are shown for comparisons between ‘established PD’ and ‘not PD’ combined with ‘probable PD’ donors with LP using t-tests for continuous variables and chi-square tests for categorical variables. * p < 0.05; ** p < 0.01; *** p < 0.001