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Table 2 Demographics and clinical characteristics of donors with LP, PSP tau pathology, GCI pathology and other types of pathology

From: Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series

 LPPSP tau pathologyGCI pathologyOther types of pathology
N162452858
Sex M, n (%)102 (63%)28 (62%)10 (36%)**36 (62%)
Age at onset y, mean ± SD (range)
<  50 / 50–75 / >  75 y, n (%)
62 ± 11 (32–88)
26/117/19 (16/72/12%)
66 ± 7 (51–84)**
0/40/5 (0/89/11%)
59 ± 9 (45–81)
3/23/2 (11/82/7%)
64 ± 12 (34–84)
7/43/8 (12/74/14%)
Age at death y, mean ± SD (range)77 ± 8 (56–96)74 ± 8 (57–90)66 ± 9 (52–84)***76 ± 11 (42–98)
Disease duration y, mean ± SD (range)15 ± 7 (2–42)8 ± 4 (3–23)***7 ± 3 (3–16)***11 ± 9 (0.5–41)**
Dementia, n (%)89 (55%)12 (27%)***2 (7%)***30 (52%)
Duration of dementia y, mean ± SD (range)4 ± 3 (0–12)2 ± 2 (0–6)**1 ± 1 (0–1)3 ± 2 (0–10)
Visual hallucinations, n/N (%)93/122 (76%)10/13 (77%)5/7 (71%)9/13 (69%)
Rest tremor, n/N (%)112/134 (84%)11/30 (37%)***16/24 (67%)29/37 (78%)
Clear response to dopaminergic therapy, n/N (%)106/126 (84%)6/26 (23%)***11/24 (46%)***10/26 (39%)***
Positive family history of parkinsonism, n/N (%)31/80 (39%)7/28 (25%)3/17 (18%)8/29 (28%)
APOE ε4 alleles, n/N (%)
 067/101 (66%)23/39 (59%)12/23 (52%)33/43 (77%)
 131/101 (31%)15/39 (39%)9/23 (39%)9/43 (21%)
 23/101 (3%)1/39 (3%)2/23 (9%)1/43 (2%)
  1. Groups are compared using analysis of covariance for continuous variables and chi-square tests for categorical variables. When significant, the LP group was compared to the other pathology groups using post-hoc tests for continuous variable and chi-square tests for categorical variables.* p < 0.05; ** p < 0.01; *** p < 0.001