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Table 1 Demographics and clinical characteristics of donors with clinically-defined PD, atypical parkinsonian disorders and donors without a definite clinical diagnosis.

From: Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series

 PDAtypical parkinsonian disordersNo definite clinical diagnosis
N17610116
Sex M, n (%)104 (59%)61 (60%)11 (69%)
Age at onset y, mean ± SD (range), <50 / 50-75 / >75 y, n (%)62 ± 11 (32–88), 26/129/21 (15/73/12%)63 ± 9 (36–81), 8/84/9 (8/83/9%)66 ± 14 (34–84), 2/10/4 (13/63/25%)
Age at death y, mean ± SD (range)77 ± 8 (56–98)72 ± 9 (42–92)***77 ± 11 (54–88)
Disease duration y, mean ± SD (range)15 ± 8 (2–42)8 ± 6 (0.5–38)***11 ± 9 (3–41)*
Dementia, n (%)90 (51%)39 (39%)*4 (25%)*
Duration of dementia y, mean ± SD (range)4 ± 3 (0–12)2 ± 2 (0–10)***4 ± 2 (2–5)
Visual hallucinations, n/N (%)95/121 (79%)22/28 (79%)0/6 (0%)***
Rest tremor, n/N (%)120/143 (84%)38/68 (56%)***10/14 (71%)
Clear response to dopaminergic therapy, n/N (%)118/135 (87%)12/55 (22%)***3/12 (25%)***
Positive family history of parkinsonism, n/N (%)33/86 (38%)14/60 (23%)2/8 (25%)
APOE ε4 alleles, n/N (%)
 078/115 (68%)48/80 (60%)9/11 (82%)
 133/115 (29%)29/80 (36%)2/11 (18%)
 24/115 (3%)3/80 (4%)0/11 (0%)
Specialization level of the diagnosing physician, n/N (%)
 Movement disorders specialist59/144 (41%)52/95 (55%)6/14 (43%)
 General neurologist76/144 (53%)37/95 (39%)4/14 (29%)
 Non-neurologist9/144 (6%)6/95 (6%)4/14 (29%)**
Year of diagnosis, mean ± SD (range)1995 ± 10 (1970 – 2012)2002 ± 6 (1988 – 2014)*** 1998 ± 10 (1979 – 2013)
  1. P-values are shown for comparisons between the PD group and the atypical parkinsonian disorders group or the group without a definite clinical diagnosis using t-tests for continuous variables and chi-square tests for categorical variables. * p < 0.05; ** p < 0.01; *** p < 0.001