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Table 1 Characteristics of patients with spinal cord astrocytoma in this study

From: The molecular characteristics of spinal cord gliomas with or without H3 K27M mutation

  TotalTotal (Grade II–IV)P-value
H3 wildtypeH3 K27M-mutant
Number 834835 
Age (year)Median31(6–63)30(6–63)35(9–52)n.s
Gender    n.s
 male49(59%)31(65%)18(51%) 
 female34(41%)17(35%)17(49%) 
Histological grade    0.0068
 II51(61%)37(77%)14(40%) 
 III20(24%)6(13%)14(40%) 
 IV12(14%)5(10%)7(20%) 
Location    n.s
 C29(35%)19(40%)10(29%) 
 C-T13(16%)6(13%)7(20%) 
 T34(41%)19(40%)15(43%) 
 T-L7(8%)4(8%)3(9%) 
Resection    < 0.0001
 GTR50(60%)38(79%)12(34%) 
 STR16(19%)6(13%)10(29%) 
 OB17(20%)4(8%)13(37%) 
Radio    n.s
 yes53(64%)30(63%)23(66%) 
 no18(22%)12(25%)6(17%) 
 unknown12(14%)6(13%)6(17%) 
Chemo    0.0484
 yes23(28%)10(21%)13(37%) 
 no47(57%)32(67%)15(43%) 
 unknown13(16%)6(13%)7(20%) 
IDH    n.s
 wildtype58(70%)33(69%)25(71%) 
 mutant0(0%)0(0%)0(0%) 
 unknown25(30%)15(31%)10(29%) 
TERT promoter    n.s
 wildtype45(54%)24(50%)21(60%) 
 mutant13(16%)9(19%)4(11%) 
 unknown25(30%)15(31%)10(29%) 
BRAF V600E    0.0141
 wildtype50(60%)26(54%)24(69%) 
 mutant7(8%)7(15%)0(0%) 
 unknown26(31%)15(31%)11(31%) 
Ki-67    < 0.0001
 < 10%44(53%)37(63%)7(20%) 
 ≥10%46(55%)18(33%)28(80%) 
 unknown3(4%)3(4%)0(0%) 
Survival (Median OS, months)40.13Und20.7< 0.0001
  1. C cervical vertebrae, C-T cervicothoracic vertebrae, T thoracic vertebrae, T-L thoracolumbar vertebrae, GTR gross total resection, STR subtotal resection, OB open biopsy, Radio Radiotherapy, Chemo Chemotherapy
  2. Significant P-values are indicated in bold text