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Table 1 Characteristics of patients with spinal cord astrocytoma in this study

From: The molecular characteristics of spinal cord gliomas with or without H3 K27M mutation

  

Total

Total (Grade II–IV)

P-value

H3 wildtype

H3 K27M-mutant

Number

 

83

48

35

 

Age (year)

Median

31(6–63)

30(6–63)

35(9–52)

n.s

Gender

    

n.s

 

male

49(59%)

31(65%)

18(51%)

 
 

female

34(41%)

17(35%)

17(49%)

 

Histological grade

    

0.0068

 

II

51(61%)

37(77%)

14(40%)

 
 

III

20(24%)

6(13%)

14(40%)

 
 

IV

12(14%)

5(10%)

7(20%)

 

Location

    

n.s

 

C

29(35%)

19(40%)

10(29%)

 
 

C-T

13(16%)

6(13%)

7(20%)

 
 

T

34(41%)

19(40%)

15(43%)

 
 

T-L

7(8%)

4(8%)

3(9%)

 

Resection

    

< 0.0001

 

GTR

50(60%)

38(79%)

12(34%)

 
 

STR

16(19%)

6(13%)

10(29%)

 
 

OB

17(20%)

4(8%)

13(37%)

 

Radio

    

n.s

 

yes

53(64%)

30(63%)

23(66%)

 
 

no

18(22%)

12(25%)

6(17%)

 
 

unknown

12(14%)

6(13%)

6(17%)

 

Chemo

    

0.0484

 

yes

23(28%)

10(21%)

13(37%)

 
 

no

47(57%)

32(67%)

15(43%)

 
 

unknown

13(16%)

6(13%)

7(20%)

 

IDH

    

n.s

 

wildtype

58(70%)

33(69%)

25(71%)

 
 

mutant

0(0%)

0(0%)

0(0%)

 
 

unknown

25(30%)

15(31%)

10(29%)

 

TERT promoter

    

n.s

 

wildtype

45(54%)

24(50%)

21(60%)

 
 

mutant

13(16%)

9(19%)

4(11%)

 
 

unknown

25(30%)

15(31%)

10(29%)

 

BRAF V600E

    

0.0141

 

wildtype

50(60%)

26(54%)

24(69%)

 
 

mutant

7(8%)

7(15%)

0(0%)

 
 

unknown

26(31%)

15(31%)

11(31%)

 

Ki-67

    

< 0.0001

 

< 10%

44(53%)

37(63%)

7(20%)

 
 

≥10%

46(55%)

18(33%)

28(80%)

 
 

unknown

3(4%)

3(4%)

0(0%)

 

Survival (Median OS, months)

40.13

Und

20.7

< 0.0001

  1. C cervical vertebrae, C-T cervicothoracic vertebrae, T thoracic vertebrae, T-L thoracolumbar vertebrae, GTR gross total resection, STR subtotal resection, OB open biopsy, Radio Radiotherapy, Chemo Chemotherapy
  2. Significant P-values are indicated in bold text