From: The molecular characteristics of spinal cord gliomas with or without H3 K27M mutation
 |  | Total | Total (Grade II–IV) | P-value | |
---|---|---|---|---|---|
H3 wildtype | H3 K27M-mutant | ||||
Number | Â | 83 | 48 | 35 | Â |
Age (year) | Median | 31(6–63) | 30(6–63) | 35(9–52) | n.s |
Gender | Â | Â | Â | Â | n.s |
 | male | 49(59%) | 31(65%) | 18(51%) |  |
 | female | 34(41%) | 17(35%) | 17(49%) |  |
Histological grade | Â | Â | Â | Â | 0.0068 |
 | II | 51(61%) | 37(77%) | 14(40%) |  |
 | III | 20(24%) | 6(13%) | 14(40%) |  |
 | IV | 12(14%) | 5(10%) | 7(20%) |  |
Location | Â | Â | Â | Â | n.s |
 | C | 29(35%) | 19(40%) | 10(29%) |  |
 | C-T | 13(16%) | 6(13%) | 7(20%) |  |
 | T | 34(41%) | 19(40%) | 15(43%) |  |
 | T-L | 7(8%) | 4(8%) | 3(9%) |  |
Resection |  |  |  |  | < 0.0001 |
 | GTR | 50(60%) | 38(79%) | 12(34%) |  |
 | STR | 16(19%) | 6(13%) | 10(29%) |  |
 | OB | 17(20%) | 4(8%) | 13(37%) |  |
Radio | Â | Â | Â | Â | n.s |
 | yes | 53(64%) | 30(63%) | 23(66%) |  |
 | no | 18(22%) | 12(25%) | 6(17%) |  |
 | unknown | 12(14%) | 6(13%) | 6(17%) |  |
Chemo | Â | Â | Â | Â | 0.0484 |
 | yes | 23(28%) | 10(21%) | 13(37%) |  |
 | no | 47(57%) | 32(67%) | 15(43%) |  |
 | unknown | 13(16%) | 6(13%) | 7(20%) |  |
IDH | Â | Â | Â | Â | n.s |
 | wildtype | 58(70%) | 33(69%) | 25(71%) |  |
 | mutant | 0(0%) | 0(0%) | 0(0%) |  |
 | unknown | 25(30%) | 15(31%) | 10(29%) |  |
TERT promoter | Â | Â | Â | Â | n.s |
 | wildtype | 45(54%) | 24(50%) | 21(60%) |  |
 | mutant | 13(16%) | 9(19%) | 4(11%) |  |
 | unknown | 25(30%) | 15(31%) | 10(29%) |  |
BRAF V600E | Â | Â | Â | Â | 0.0141 |
 | wildtype | 50(60%) | 26(54%) | 24(69%) |  |
 | mutant | 7(8%) | 7(15%) | 0(0%) |  |
 | unknown | 26(31%) | 15(31%) | 11(31%) |  |
Ki-67 |  |  |  |  | < 0.0001 |
 | < 10% | 44(53%) | 37(63%) | 7(20%) |  |
 | ≥10% | 46(55%) | 18(33%) | 28(80%) |  |
 | unknown | 3(4%) | 3(4%) | 0(0%) |  |
Survival (Median OS, months) | 40.13 | Und | 20.7 | < 0.0001 |