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Table 3 Summary of data on cytosolic proteome solubility

From: Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

Mouse model Strain background Age assessed Total Aβ burden assessed by CS-silver stain # Animals # of cytosolic proteins identified as over-represented in SDS insoluble fractions
Pairwise only Pairwise and SAINT > 0.9 SAINT Score only
PrP.HuAβ/PS1 B6/C3 20 mo +++ 3 101 87 103
PrP.MoAβ/PS1 B6/C3 24 mo + 2 2 0 0
Bri42Homo B6/C3 15 mo +++ 3 9 0 5
PrP.APPsi B6/C3 25 mo +++ 3 3 0 4
NTg B6/C3 12 mo 1    
16 mo 1    
20 mo 2    
Tet.HuAβ B6/FVB F1 2.5 mo 3 0 0 0
Tet.HuAβ B6/FVB F1 13 mo +++ 4 89 80 139
Tet.MoAβ B6/FVB F1 24 mo +++ 3 131 38 48
Tet.Bri42 B6/FVB F1 7–8 mo +++ 4 32 12 15
NTg B6/FVB F1 2.5 mo - 2    
13 mo - 6a    
24 mo - 2    
  1. aIncludes 4 mice that were treated with Dox for 1 or 4 weeks (2 each). The raw data used to produce this table are available as excel files in Additional files 3, 4 and 5, Tables S2, S3 and S4