Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

Table 3 Summary of data on cytosolic proteome solubility

Mouse model	Strain background	Age assessed	Total Aβ burden assessed by CS-silver stain	# Animals	# of cytosolic proteins identified as over-represented in SDS insoluble fractions
Mouse model	Strain background	Age assessed	Total Aβ burden assessed by CS-silver stain	# Animals	Pairwise only	Pairwise and SAINT > 0.9	SAINT Score only
PrP.HuAβ/PS1	B6/C3	20 mo	+++	3	101	87	103
PrP.MoAβ/PS1	B6/C3	24 mo	+	2	2	0	0
Bri42Homo	B6/C3	15 mo	+++	3	9	0	5
PrP.APPsi	B6/C3	25 mo	+++	3	3	0	4
NTg	B6/C3	12 mo	–	1
		16 mo	–	1
		20 mo	–	2
Tet.HuAβ	B6/FVB F1	2.5 mo	–	3	0	0	0
Tet.HuAβ	B6/FVB F1	13 mo	+++	4	89	80	139
Tet.MoAβ	B6/FVB F1	24 mo	+++	3	131	38	48
Tet.Bri42	B6/FVB F1	7–8 mo	+++	4	32	12	15
NTg	B6/FVB F1	2.5 mo	-	2
		13 mo	-	6^a
		24 mo	-	2

^aIncludes 4 mice that were treated with Dox for 1 or 4 weeks (2 each). The raw data used to produce this table are available as excel files in Additional files 3, 4 and 5, Tables S2, S3 and S4

ISSN: 2051-5960