|
Mouse model
|
Strain background
|
Age assessed
|
Total Aβ burden assessed by CS-silver stain
|
# Animals
|
# of cytosolic proteins identified as over-represented in SDS insoluble fractions
|
|---|
|
Pairwise only
|
Pairwise and SAINT > 0.9
|
SAINT Score only
|
|---|
|
PrP.HuAβ/PS1
|
B6/C3
|
20 mo
|
+++
|
3
|
101
|
87
|
103
|
|
PrP.MoAβ/PS1
|
B6/C3
|
24 mo
|
+
|
2
|
2
|
0
|
0
|
|
Bri42Homo
|
B6/C3
|
15 mo
|
+++
|
3
|
9
|
0
|
5
|
|
PrP.APPsi
|
B6/C3
|
25 mo
|
+++
|
3
|
3
|
0
|
4
|
|
NTg
|
B6/C3
|
12 mo
|
–
|
1
| | | |
|
16 mo
|
–
|
1
| | | |
|
20 mo
|
–
|
2
| | | |
|
Tet.HuAβ
|
B6/FVB F1
|
2.5 mo
|
–
|
3
|
0
|
0
|
0
|
|
Tet.HuAβ
|
B6/FVB F1
|
13 mo
|
+++
|
4
|
89
|
80
|
139
|
|
Tet.MoAβ
|
B6/FVB F1
|
24 mo
|
+++
|
3
|
131
|
38
|
48
|
|
Tet.Bri42
|
B6/FVB F1
|
7–8 mo
|
+++
|
4
|
32
|
12
|
15
|
|
NTg
|
B6/FVB F1
|
2.5 mo
|
-
|
2
| | | |
|
13 mo
|
-
|
6a
| | | |
|
24 mo
|
-
|
2
| | | |
- aIncludes 4 mice that were treated with Dox for 1 or 4 weeks (2 each). The raw data used to produce this table are available as excel files in Additional files 3, 4 and 5, Tables S2, S3 and S4
