Table 2 Semi-quantitative comparison of the neuropathological features of mouse models at the ages used for LC-MS/MS studies. Scoring criteria described in materials and methods
Mouse models (age assessed) | N | Staining Method | |||||||
|---|---|---|---|---|---|---|---|---|---|
Silver | Thio S | Congo Red | 33.1.1 | 4G8 | Ubiquitin | GFAP | Iba1 | ||
Diffuse & Cored Aβ | Cored Fibrillary Aβ | Cored Fibrillary Aβ | Aβ | Aβ | Cored-Neuritic Deposits | astrocytes | microglia | ||
Bri42Homo (15–18 mo) | M3 F1 | +++ | + | + | ++ | + | + | ++ | + |
Tet.Bri42 (7–8 mo) | M1 F3 | +++ | ++ | ++ | ++ | + | + | ++ | +/− |
PrP.HuAβ/PS1 (16–20 mo) | M1 F3 | +++ | +++ | +++ | +++ | + | ++ | +++ | ++ |
PrP.MoAβ/PS1 (24 mo) | M1 F2 | + | + | + | + | + | +/− | + | +/− |
PrP.APPsi (25 mo) | M1 F2 | +++ | +/− | +/− | +++ | +/− | +/− | + | +/− |
Tet.MoAβ (24 mo) | M1 F2 | +++ | +/− | +/− | +++ | +/− | +/− | + | + |
Tet.HuAβ (12 mo) | M2 F2 | +++ | +++ | +++ | +++ | ++ | +++ | +++ | ++ |