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Table 2 Semi-quantitative comparison of the neuropathological features of mouse models at the ages used for LC-MS/MS studies. Scoring criteria described in materials and methods

From: Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

Mouse models
(age assessed)
N Staining Method
Silver Thio S Congo Red 33.1.1 4G8 Ubiquitin GFAP Iba1
Diffuse & Cored Aβ Cored Fibrillary Aβ Cored Fibrillary Aβ Cored-Neuritic Deposits astrocytes microglia
Bri42Homo
(15–18 mo)
M3
F1
+++ + + ++ + + ++ +
Tet.Bri42
(7–8 mo)
M1
F3
+++ ++ ++ ++ + + ++ +/−
PrP.HuAβ/PS1
(16–20 mo)
M1
F3
+++ +++ +++ +++ + ++ +++ ++
PrP.MoAβ/PS1
(24 mo)
M1
F2
+ + + + + +/− + +/−
PrP.APPsi
(25 mo)
M1
F2
+++ +/− +/− +++ +/− +/− + +/−
Tet.MoAβ
(24 mo)
M1
F2
+++ +/− +/− +++ +/− +/− + +
Tet.HuAβ
(12 mo)
M2
F2
+++ +++ +++ +++ ++ +++ +++ ++