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Table 2 Semi-quantitative comparison of the neuropathological features of mouse models at the ages used for LC-MS/MS studies. Scoring criteria described in materials and methods

From: Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

Mouse models
(age assessed)
NStaining Method
SilverThio SCongo Red33.1.14G8UbiquitinGFAPIba1
Diffuse & Cored AβCored Fibrillary AβCored Fibrillary AβCored-Neuritic Depositsastrocytesmicroglia
Bri42Homo
(15–18 mo)
M3
F1
++++++++++++
Tet.Bri42
(7–8 mo)
M1
F3
++++++++++++++/−
PrP.HuAβ/PS1
(16–20 mo)
M1
F3
++++++++++++++++++++
PrP.MoAβ/PS1
(24 mo)
M1
F2
++++++/−++/−
PrP.APPsi
(25 mo)
M1
F2
++++/−+/−++++/−+/−++/−
Tet.MoAβ
(24 mo)
M1
F2
++++/−+/−++++/−+/−++
Tet.HuAβ
(12 mo)
M2
F2
++++++++++++++++++++++