Skip to main content

Table 1 Attributes of the mouse models used in this study

From: Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

Model Designation Other names Vector Transgenes
species
Onset Aβ deposition (mo) Neuropath features of aged animals Reference
Bri42 Homo HBri Mo.PrP Bri-HuAβ42 (homozygous) Hu ~ 3 Diffuse > Cored, Thio + [26]
Tet.Bri42 Bri42 x tTA Tet-PrP CamKII-tTA Bri-HuAβ42, tTA Hu < 2 Diffuse ≈ Cored, Thio + Current study
PrP.HuAβ/
PS1
APPswe/PS1dE9 Line 85 Mo.PrP m/hAPPswe+PS1dE9 Hu ~ 6 Cored> > diffuse, Thio + with CAA [13]
PrP.MoAβ/
PS1
MoAPPswe/PS1dE9, Line D-943 Mo.PrP moAPPswe+PS1dE9 Mo ~ 14 Cored Thio + with CAA [41]
PrP.APPsi MHSI-695, PrP.HuAβ (GFP) Mo.PrP m/hAPPswe/ind, eGFP Hu ~ 12 Diffuse > > Cored, Thio + [41]
Tet.MoAβ Tet-moAPPsi, moAPPxtTA Tet-PrP CamKII-tTA moAPPswe/ind, tTA, eGFP Mo ~ 13 Diffuse [41]
Tet.HuAβ Tet.APPsi, 107 x tTA Tet-PrP CamKII-tTA m/hAPPswe/ind, tTA Hu ~ 3 Cored>diffuse, Thio + [14]