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Table 1 Attributes of the mouse models used in this study

From: Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

Model DesignationOther namesVectorTransgenes
species
Onset Aβ deposition (mo)Neuropath features of aged animalsReference
Bri42 HomoHBriMo.PrPBri-HuAβ42 (homozygous)Hu~ 3Diffuse > Cored, Thio +[26]
Tet.Bri42Bri42 x tTATet-PrP CamKII-tTABri-HuAβ42, tTAHu< 2Diffuse ≈ Cored, Thio +Current study
PrP.HuAβ/
PS1
APPswe/PS1dE9 Line 85Mo.PrPm/hAPPswe+PS1dE9Hu~ 6Cored> > diffuse, Thio + with CAA[13]
PrP.MoAβ/
PS1
MoAPPswe/PS1dE9, Line D-943Mo.PrPmoAPPswe+PS1dE9Mo~ 14Cored Thio + with CAA[41]
PrP.APPsiMHSI-695, PrP.HuAβ (GFP)Mo.PrPm/hAPPswe/ind, eGFPHu~ 12Diffuse > > Cored, Thio +[41]
Tet.MoAβTet-moAPPsi, moAPPxtTATet-PrP CamKII-tTAmoAPPswe/ind, tTA, eGFPMo~ 13Diffuse[41]
Tet.HuAβTet.APPsi, 107 x tTATet-PrP CamKII-tTAm/hAPPswe/ind, tTAHu~ 3Cored>diffuse, Thio +[14]