Table 1 Attributes of the mouse models used in this study
Model Designation | Other names | Vector | Transgenes | Aβ species | Onset Aβ deposition (mo) | Neuropath features of aged animals | Reference |
|---|---|---|---|---|---|---|---|
Bri42 Homo | HBri | Mo.PrP | Bri-HuAβ42 (homozygous) | Hu | ~ 3 | Diffuse > Cored, Thio + | [26] |
Tet.Bri42 | Bri42 x tTA | Tet-PrP CamKII-tTA | Bri-HuAβ42, tTA | Hu | < 2 | Diffuse ≈ Cored, Thio + | Current study |
PrP.HuAβ/ PS1 | APPswe/PS1dE9 Line 85 | Mo.PrP | m/hAPPswe+PS1dE9 | Hu | ~ 6 | Cored> > diffuse, Thio + with CAA | [13] |
PrP.MoAβ/ PS1 | MoAPPswe/PS1dE9, Line D-943 | Mo.PrP | moAPPswe+PS1dE9 | Mo | ~ 14 | Cored Thio + with CAA | [41] |
PrP.APPsi | MHSI-695, PrP.HuAβ (GFP) | Mo.PrP | m/hAPPswe/ind, eGFP | Hu | ~ 12 | Diffuse > > Cored, Thio + | [41] |
Tet.MoAβ | Tet-moAPPsi, moAPPxtTA | Tet-PrP CamKII-tTA | moAPPswe/ind, tTA, eGFP | Mo | ~ 13 | Diffuse | [41] |
Tet.HuAβ | Tet.APPsi, 107 x tTA | Tet-PrP CamKII-tTA | m/hAPPswe/ind, tTA | Hu | ~ 3 | Cored>diffuse, Thio + | [14] |