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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

Fig. 4

Aβ 40 and 42 levels in the APP and APP/PS1 amyloidosis models used in this study. The levels of Aβ in the forebrains of mice were measured by ELISA assay as described in Materials and Methods. The ages of the mice at the time of analysis is noted in the x-axis of the figure. The blue box plots and dots mark the levels of Aβ42 whereas the red dots and box plots mark the levels of Aβ 40. Each dot represents a value detected from one animal. The average value in each set of samples is noted by the horizontal lines in the box plots. The number of animals harvested for each genotype were as follows: Tet.HuAβ (n = 5), PrP.HuAβ/PS1 (n = 12), Tet.MoAβ (n = 4), PrP.APPsi (n = 6), and PrP.MoAβ/PS1 (n = 6). Since the Bri42 and Tet.Bri42 mice do not produce Aβ40, they were not included in this study, which was meant to assess the relative levels of Aβ40 and 42 across the APP and APP/PS1 models that could produce both peptides

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