Skip to main content

Advertisement

Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy

Fig. 2

Motor axon loss in muscle specific Bicd2 knockout mice. a shows the total number of axons at 21 days of age in Bicd2+/+ mice (blue), Bicd2loxP/loxP mice in which both Bicd2 alleles are flanked by loxP sites (pink), mice with motor neuron specific Bicd2 knockout (ChAT-Cre, red), mice with muscle-specific Bicd2 knockout (Myod-Cre, green), and Bicd2−/− mice (orange). A significant reduction in the total number of L4 ventral axons was found in Myod-Cre and Bicd2−/− mice compared to wild type (one-way ANOVA p = 0.0187, Dunnett’s 2-sided t-test with Bicd2+/+ as control, **p = 0.019, *p = 0.034). b shows a histogram of the total number of L4 ventral axons at 21 days of age classified using 0.2 μm bins (pink = Bicd2loxP/loxP, red = ChAT-Cre). c shows a histogram of the total number of L4 motor axons at 21 days of age classified using 0.2 μm bins (pink = Bicd2loxP/loxP, green = Myod-Cre); multiple t-tests corrected for multiple comparisons using the Holm-Sidak method, ***p = 0.0009. d shows a histogram of the total number of L4 motor axons at 42 days of age classified using 0.4 μm bins (pink = Bicd2loxP/loxP (n = 4), green = Myod-Cre (n = 6); multiple t-tests corrected for multiple comparisons using the Holm-Sidak method,****p = 0.0002). Error bars = SEM

Back to article page