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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy

Fig. 1

Loss of motor axons in Bicd2−/− mice at 21 days of age. a shows the number of motor axons in the L4 ventral root of Bicd2+/+ (wild type) and Bicd2−/− (knockout) mice (**unpaired 2-sided t-test, p = 0.0041). b shows a histogram of the total number of L4 motor axons classified using 0.2 μm bins (blue = Bicd2+/+, orange = Bicd2−/−), *p < 0.001; multiple t-tests corrected for multiple comparisons using the Holm-Sidak method. c Representative images from 0.8 μm cross-sections of 1% toluene blue stained L4 ventral roots of Bicd2+/+ and Bicd2−/− mice. d shows the number of sensory axons in the L4 dorsal root of Bicd2+/+ and Bicd2−/− mice. e shows a histogram of the total number of L4 sensory axons classified as in b (blue = Bicd2+/+, orange = Bicd2−/−). f Representative images from 0.8 μm cross sections of 1% toluene blue stained L4 dorsal roots of Bicd2+/+ and Bicd2−/− mice. Error bars = standard error of the mean (SEM). Scale bars = 50 μm

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