Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients

Table 3 Functional Epigenetic Modules

Fraction	Seed	P value	Function
5mC	FCER1G	0.006	Antibody-binding receptor
	ELN	0.011	Elastic fiber formation
	MDFI	0.012	Repression of myogenesis
	TNF	0.035	Cytokine
	DNMT3B	0.038	DNA methyltransferase
	VAMP8	0.047	Synaptic vesicle function
5hmC	GRK2	0.004	GPCR
	SNRPB	0.008	Ribonucleoprotein
	SSTR3	0.009	Somatostatin receptor
	ITGA4	0.019	Lymphocyte homing receptor
	ZBTB16	0.023	Zinc finger transcription factor

Summarization of identified functional epigenetic modules calculated for both the 5-methylcytosine (5mC) and the 5-hydroxymethylcytosine (5hmC) fractions. Seed: Center gene of module