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Table 2 Differentially Methylated Probes

From: Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients

Fraction

Probe ID

Chr

Position

Gene

Gene feature

CpG island

Δβ (%)

P

Adj. P

chromHMM

Function

5mC

cg08753407

14

75,151,317

AREL1

Body

Open sea

−0.09

1.47E-07

3.60E-02

5_TxWk

Ubiquitination and antigen presentation

5mC

cg03452759

2

31,467,215

 

IGR

Open sea

0.03

1.91E-07

3.60E-02

15_Quies

 

5mC

cg24646067

5

87,812,057

 

IGR

Open sea

−0.08

2.00E-07

3.60E-02

15_Quies

 

5mC

cg27312312

14

56,046,001

KTN1

TSS1500

Shore

0.04

2.08E-07

3.60E-02

1_TssA

Microtubulue-associated protein

5mC

cg16096172

6

46,924,482

 

IGR

Open sea

0.03

2.46E-07

3.60E-02

15_Quies

 
  1. Differentially methylated probes (FDR < 0.05) in the 5-methylcytosine (5mC) fraction. Probe ID Illumina probe ID, Chr chromosome, Position chromosomal position, chromHMM ChromHMM [40] data for the dorsolateral prefrontal cortex; 5_TxWk weak transcription activity, 15_Quies quiescent transcription, 1_TssA active TSS