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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients

Fig. 3

Expression of AREL1, MHC Class I HLAs and blood CD14+CD16++ monocyte changes. a-b RT-qPCR experiments quantifying AREL1 (a) or MHC Class I HLAs (HLA-A, −B, −C, −E, −F, −G; b). Data were normalized to the geometric mean of three reference genes UBE2D2, RPL13, and TOP1 [49]. c Dot plot showing normalized expression of AREL1 in oligodendrocytes, astrocytes, inhibitory neurons, excitatory neurons, oligodendrocyte precursor cells (OPCs), and microglia cells from five healthy human frontal cortical samples. Data for 11,577 cells are shown. d Levels of non-classical CD14+CD16++ monocytes in peripheral blood mononuclear cells as the fraction of TCRCD3 cells. Boxes show 1st (Q1) to 3rd (Q3) quartile of data, the horizontal line shows the median, and the whiskers show Q1-inter quartile range (IQR; lower whisker) or Q3 + IQR (upper whisker). Outliers are shown with dots

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