Fig. 1

CpG probe distribution. a-h Locations of differentially methylated probes in multiple system atrophy (MSA) patients and normal, healthy controls (CTRLs) for the 5-methylcytosine (5mC; a-d) or 5-hydroxymethylcytosine (5hmC; e-h) fractions at FDR < 0.20. Probe distributions are shown for a,e intergenic or gene bound genomic areas; b,f 200 or 1500 bases upstream of transcription start site (TSS), in gene bodies, at the 3′ or 5′ untranslated region (UTR), or in the first exon; c,g in CpG island, shelf or shore areas, or in open sea areas; d,h and the CpG positions according to chromHMM tracks for the dorsolateral prefrontal cortex (TssA: active TSS; TssAFlnk: flanking TssA; Tx: strong transcription; TxWk: weak transcription; EnhG: genic enhancer; Enh: enhancer; ReprPC: repressed PolyComb; ReprPCWk: weak ReprPC; Quies: quiescent or low transcription)