Skip to main content

Table 5 GOs going down with age “granger-causing” GO synaptic transmission

From: Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain

Term

ts2_c_ts1_p

ts1_c_ts2_p

Microtubule nucleation

0.0041

0.0296

Nuclear lamina

0.0057

0.0501

Physiological muscle hypertrophy

0.0080

0.1201

Cell growth involved in cardiac muscle cell development

0.0080

0.1201

Lysophosphatidic acid binding

0.0092

0.3682

Positive regulation of dendrite morphogenesis

0.0094

0.3850

Cyclic purine nucleotide metabolic process

0.0098

0.0463

Regulation of synaptic transmission, glutamatergic

0.0114

0.0279

Dermatan sulfate biosynthetic process

0.0124

0.8968

Positive regulation of cAMP metabolic process

0.0125

0.2016

Positive regulation of cyclic nucleotide biosynthetic process

0.0125

0.2016

Uropod

0.0130

0.7732

1-phosphatidylinositol-4-phosphate 5-kinase activity

0.0130

0.7732

Proton-transporting V-type ATPase, V0 domain

0.0153

0.0617

Regulation of cAMP biosynthetic process

0.0160

0.0609

Regulation of cyclic nucleotide metabolic process

0.0160

0.0609

Synaptic vesicle docking

0.0180

0.2162

Cell-matrix adhesion

0.0183

0.0998

rRNA 3′-end processing

0.0186

0.0670

Asymmetric stem cell division

0.0192

0.1360

Rac GTPase binding

0.0197

0.5859

Macromolecular complex assembly

0.0203

0.0231

Golgi cis cisterna

0.0213

0.1023

Endomembrane system

0.0217

0.0247

Intrinsic apoptotic signaling pathway in response to oxidative stress

0.0222

0.1157

Positive regulation of purine nucleotide biosynthetic process

0.0241

0.1792

Positive regulation of nucleotide metabolic process

0.0249

0.1746

Muscle tissue development

0.0249

0.0884

Transporter activity

0.0250

0.0323

Spindle microtubule

0.0256

0.0620

Striated muscle cell development

0.0264

0.0765

Neuromuscular junction development

0.0269

0.3610

Regulation of nucleotide biosynthetic process

0.0275

0.0665

Endoplasmic reticulum

0.0356

0.0755

Calcium:cation antiporter activity

0.0385

0.3791

Ligand-gated channel activity

0.0400

0.0526

Lipid modification

0.0412

0.3182

Phosphatidylinositol phosphorylation

0.0429

0.6188

Proteoglycan biosynthetic process

0.0433

0.7653

Regulation of purine nucleotide metabolic process

0.0442

0.0842

Positive regulation of nucleocytoplasmic transport

0.0445

0.1855

Chloride channel inhibitor activity

0.0464

0.2701

Regulation of synaptic vesicle transport

0.0469

0.0834

Glutamate secretion

0.0480

0.0499

Dendrite terminus

0.0481

0.7091

  1. ts2_c_ts1_p: p-value from Granger test between time series 2 (ts2,synaptic transmission) and ts1 (order of lags = 4)
  2. ts1_c_ts2_p: p-value from Granger test between ts1 and ts2 (order of lags = 4)
  3. Significant p-values < 0.05 are marked in bold