Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain

Table 4 GOs going up with age “granger-causing” GO synaptic transmission

Term	ts2_c_ts1_p	ts1_c_ts2_p
Nitric oxide metabolic process	0.0027	0.1969
Regulation of nitric-oxide synthase biosynthetic process	0.0034	0.1853
Positive regulation of nitric oxide biosynthetic process	0.0081	0.3591
Positive regulation of myelination	0.0107	0.0538
Negative regulation of monocyte chemotactic protein-1 production	0.0142	0.5627
Regulation of cell-matrix adhesion	0.0151	0.0445
Schwann cell development	0.0207	0.0897
Histamine secretion	0.0370	0.0772
Azole transport	0.0370	0.0772
Positive regulation of reactive oxygen species metabolic process	0.0372	0.3284
Macrophage activation	0.0386	0.9125
Skin development	0.0436	0.4341
Renal absorption	0.0451	0.9061
Response to muscle stretch	0.0497	0.3531

ts2_c_ts1_p: p-value from Granger test between time series 2 (ts2,synaptic transmission) and ts1 (order of lags = 4)
ts1_c_ts2_p: p-value from Granger test between ts1 and ts2 (order of lags = 4)
Significant p-values < 0.05 are marked in bold

ISSN: 2051-5960