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Table 2 Selected groups of significant GO terms overrepresented in genes anti-correlated with age in female and male

From: Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain

GroupTerm_femaleP value_FTerm_maleP value_M
Catecholaminecatecholamine uptake involved in synaptic transmission1.47E-04catecholamine secretion5.33E-04
cellular response to catecholamine stimulus8.13E-04  
catecholamine transport1.47E-03  
regulation of catecholamine secretion1.76E-02  
catecholamine binding4.99E-02  
Hormonehormone transport8.20E-07hormone transport6.75E-07
regulation of hormone secretion2.56E-06regulation of hormone secretion3.64E-06
peptide hormone secretion4.88E-05peptide hormone secretion1.77E-05
response to peptide hormone1.01E-03response to peptide hormone2.62E-05
hormone-mediated apoptotic signaling pathway4.18E-03cellular response to hormone stimulus1.11E-04
cellular response to hormone stimulus5.97E-03positive regulation of peptide hormone secretion9.68E-03
negative regulation of peptide hormone secretion6.89E-03hormone-mediated apoptotic signaling pathway1.06E-02
regulation of intracellular steroid hormone receptor signaling pathway1.97E-02thyroid hormone transport1.72E-02
neuropeptide hormone activity2.45E-06positive regulation of corticosteroid hormone secretion3.41E-02
  regulation of intracellular steroid hormone receptor signaling pathway3.90E-02
  cellular response to parathyroid hormone stimulus4.42E-02
  neuropeptide hormone activity6.12E-05
  peptide hormone receptor binding7.63E-03
Corticoidpositive regulation of glucocorticoid receptor signaling pathway1.94E-05positive regulation of glucocorticoid receptor signaling pathway8.12E-05
corticosteroid receptor signaling pathway1.17E-03corticosteroid receptor signaling pathway6.59E-03
  positive regulation of corticosteroid hormone secretion3.41E-02
Neurogenesispositive regulation of neurogenesis2.84E-05positive regulation of neurogenesis1.51E-05
negative regulation of neurogenesis3.31E-03  
cAMPregulation of cAMP biosynthetic process7.42E-05regulation of cAMP biosynthetic process6.39E-07
negative regulation of cAMP metabolic process7.43E-04negative regulation of cAMP metabolic process5.18E-05
positive regulation of cAMP metabolic process1.01E-02positive regulation of cAMP metabolic process4.47E-04
  hippocampus development7.40E-04
  cAMP-mediated signaling9.50E-04
  negative regulation of cAMP-mediated signaling3.86E-03
  cAMP catabolic process4.08E-02
LTPpositive regulation of long-term synaptic potentiation6.25E-04long-term synaptic potentiation5.54E-06
long-term synaptic potentiation4.07E-03positive regulation of long-term synaptic potentiation2.49E-03
Dendritic spinenegative regulation of dendritic spine development2.02E-03dendritic spine morphogenesis4.75E-05
dendritic spine organization3.74E-03regulation of dendritic spine morphogenesis2.44E-03
regulation of dendritic spine morphogenesis5.59E-03negative regulation of dendritic spine development7.75E-03
dendritic spine development9.70E-03positive regulation of dendritic spine morphogenesis1.03E-02
positive regulation of dendritic spine morphogenesis3.38E-02dendritic spine4.60E-09
dendritic spine5.69E-05dendritic spine head2.26E-03
dendritic spine head5.73E-04  
dendritic spine membrane2.17E-02