Table 2 Selected groups of significant GO terms overrepresented in genes anti-correlated with age in female and male
Group | Term_female | P value_F | Term_male | P value_M |
|---|---|---|---|---|
Catecholamine | catecholamine uptake involved in synaptic transmission | 1.47E-04 | catecholamine secretion | 5.33E-04 |
cellular response to catecholamine stimulus | 8.13E-04 | Â | Â | |
catecholamine transport | 1.47E-03 | Â | Â | |
regulation of catecholamine secretion | 1.76E-02 | Â | Â | |
catecholamine binding | 4.99E-02 | Â | Â | |
Hormone | hormone transport | 8.20E-07 | hormone transport | 6.75E-07 |
regulation of hormone secretion | 2.56E-06 | regulation of hormone secretion | 3.64E-06 | |
peptide hormone secretion | 4.88E-05 | peptide hormone secretion | 1.77E-05 | |
response to peptide hormone | 1.01E-03 | response to peptide hormone | 2.62E-05 | |
hormone-mediated apoptotic signaling pathway | 4.18E-03 | cellular response to hormone stimulus | 1.11E-04 | |
cellular response to hormone stimulus | 5.97E-03 | positive regulation of peptide hormone secretion | 9.68E-03 | |
negative regulation of peptide hormone secretion | 6.89E-03 | hormone-mediated apoptotic signaling pathway | 1.06E-02 | |
regulation of intracellular steroid hormone receptor signaling pathway | 1.97E-02 | thyroid hormone transport | 1.72E-02 | |
neuropeptide hormone activity | 2.45E-06 | positive regulation of corticosteroid hormone secretion | 3.41E-02 | |
| Â | Â | regulation of intracellular steroid hormone receptor signaling pathway | 3.90E-02 | |
| Â | Â | cellular response to parathyroid hormone stimulus | 4.42E-02 | |
| Â | Â | neuropeptide hormone activity | 6.12E-05 | |
| Â | Â | peptide hormone receptor binding | 7.63E-03 | |
Corticoid | positive regulation of glucocorticoid receptor signaling pathway | 1.94E-05 | positive regulation of glucocorticoid receptor signaling pathway | 8.12E-05 |
corticosteroid receptor signaling pathway | 1.17E-03 | corticosteroid receptor signaling pathway | 6.59E-03 | |
| Â | Â | positive regulation of corticosteroid hormone secretion | 3.41E-02 | |
Neurogenesis | positive regulation of neurogenesis | 2.84E-05 | positive regulation of neurogenesis | 1.51E-05 |
negative regulation of neurogenesis | 3.31E-03 | Â | Â | |
cAMP | regulation of cAMP biosynthetic process | 7.42E-05 | regulation of cAMP biosynthetic process | 6.39E-07 |
negative regulation of cAMP metabolic process | 7.43E-04 | negative regulation of cAMP metabolic process | 5.18E-05 | |
positive regulation of cAMP metabolic process | 1.01E-02 | positive regulation of cAMP metabolic process | 4.47E-04 | |
| Â | Â | hippocampus development | 7.40E-04 | |
| Â | Â | cAMP-mediated signaling | 9.50E-04 | |
| Â | Â | negative regulation of cAMP-mediated signaling | 3.86E-03 | |
| Â | Â | cAMP catabolic process | 4.08E-02 | |
LTP | positive regulation of long-term synaptic potentiation | 6.25E-04 | long-term synaptic potentiation | 5.54E-06 |
long-term synaptic potentiation | 4.07E-03 | positive regulation of long-term synaptic potentiation | 2.49E-03 | |
Dendritic spine | negative regulation of dendritic spine development | 2.02E-03 | dendritic spine morphogenesis | 4.75E-05 |
dendritic spine organization | 3.74E-03 | regulation of dendritic spine morphogenesis | 2.44E-03 | |
regulation of dendritic spine morphogenesis | 5.59E-03 | negative regulation of dendritic spine development | 7.75E-03 | |
dendritic spine development | 9.70E-03 | positive regulation of dendritic spine morphogenesis | 1.03E-02 | |
positive regulation of dendritic spine morphogenesis | 3.38E-02 | dendritic spine | 4.60E-09 | |
dendritic spine | 5.69E-05 | dendritic spine head | 2.26E-03 | |
dendritic spine head | 5.73E-04 | Â | Â | |
dendritic spine membrane | 2.17E-02 | Â | Â |