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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain

Fig. 6

Protein interaction networks highlight major role of astrocyte marker GFAP during aging. a Protein interaction network of proteins coded by genes down-regulated with age based on interactions from the BioGrid database. G-protein subunit alpha L (GNAL) is at the center of several clusters which are characterized by hub proteins BABAM1 (red), GNAS (yellow), TRIM25 (petrol), SPATA2 (green), APP (violet) and ELAVL1 (blue). b Protein interaction network of proteins coded by genes up-regulated with age based on interactions from the BioGrid database. The astrocyte marker-GFAP, has a central role and is directly connected to APP

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