Fig. 5

Pathways down-regulated during aging are associated with various types of synapses, calcium signaling and long-term potentiation while up-regulated pathways are associated with the extracellular matrix, cytoskeleton, Hippo- and PI3K-Akt signaling. KEGG pathways of genes which were most significantly correlated and anti-correlated with age were analyzed separately for male and female prefrontal cortex. In both sexes pathways related to various types of synapses, calcium signaling and long-term potentiation were found overrepresented in the genes anti-correlated with age. In the genes correlated with age pathways associated with the extracellular matrix, cytoskeleton, Hippo- and PI3K-Akt -signaling are overrepresented