Fig. 2
Most genes were differentially expressed between groups of age > 65 and age < 30. Down-regulated (a, c, e) and up-regulated (b, d, f) genes were compared in venn diagrams between female (red circles) and male (green circles) prefrontal cortex. Age was grouped in a sex-specific way into age < 30 (F30, M30), 30 < age < 65 (F30_65, M30_65) and age > 65 (F65, M65). a Genes down-regulated in F30_65 vs. F30 were compared with genes down-regulated in M30_65 vs. M30. b Genes up-regulated in F30_65 vs. F30 were compared with genes up-regulated in M30_65 vs. M30. c Genes down-regulated in F65 vs. F30_65 were compared with genes down-regulated in M65 vs. M30_65. d Genes up-regulated in F65 vs. F30_65 were compared with genes up-regulated in M65 vs. M30_65. e Genes down-regulated in F65 vs. F30 were compared with genes down-regulated in M65 vs. M30. f Genes up-regulated in F65 vs. F30 were compared with genes up-regulated in M65 vs. M30. Most genes were differentially expressed between the more distant groups of age > 65 and age < 30 while in the comparisons between the adjacent age groups there were fewer genes differentially expressed. This demonstrates continuous long-term changes in gene expression. From the fewer genes differentially expressed in male biopsies most were in common with the female genes