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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape

Fig. 4

Immune phenotyping of the peripheral blood during disease evolution. a Overview of the main immune subpopulations (left panel), CD4/CD8 ratio (middle panel) and specific T cell subsets (right panel). b T cell activation of CD8+ (upper) and CD4+ (lower panel) T cells, as defined by their surface expression of the high affinity IL-2 receptor (CD25) and CD69. c Expression of checkpoint molecules Killer cell lectin-like receptor subfamily G member 1 (KLRG1), CD57, programmed death-1 (PD-1) and T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) on CD8+ (upper) and CD4+ (lower panel) T cells. d T cell differentiation defined by CD45RA/CCR7/CD28 marker expression. TNV = naïve (CD45RA+, CCR7+, CD28+), TCM = central memory (CD45RA, CCR7+, CD28+), TTM = transitional memory (CD45RA, CCR7, CD28+), TEM = effector memory (CD45RA, CCR7, CD28), TTE = terminal effector (CD45RA+, CCR7, CD28)

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