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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Altered secretory and neuroprotective function of the choroid plexus in progressive multiple sclerosis

Fig. 4

Expression of ADM, SERPINE1 (PAI-1) and STC2 by choroid plexus epithelial cells. aADM, SERPINE1 and STC2 mRNA expression in the CP of progressive MS patients and controls as assessed by RT-qPCR. Data are normalised to both 18 s rRNA and GAPDH. Results are displayed as fold change relative to control CP (n = 6 CP per group) and presented as mean ± SEM. Differences were tested by two-tailed Welch t-test. bADM, SERPINE1 and STC2 mRNA expression in human choroid plexus epithelial cells (HIBCPP) exposed to hypoxic (1% O2) or normoxic (20% O2) conditions. Data are normalised to 18 s rRNA. Results are displayed as the negative difference in Ct values between each gene and 18 s rRNA (−ΔCt) and presented as median and interquartile ranges (IQR). Data from triplicate wells in 5 to 6 independent experiments. Differences were tested by two-tailed Welch t-test. cADM, SERPINE1 and STC2 mRNA expression in human choroid plexus epithelial cells (HIBCPP) exposed to the inflammatory cytokine TNFα (10 ng/mL). Data are normalised to 18 s rRNA. Results are displayed as the negative difference in Ct values between each gene and 18 s rRNA (−ΔCt) and presented as median and interquartile ranges (IQR). Data from triplicate wells in 6 independent experiments. Differences were tested by two-tailed Welch t-test

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