Fig. 1

Transcriptional profile of the human choroid plexus in progressive MS. a Volcano plot of statistical significance against fold change between CP of progressive MS cases (n = 6) and that of controls (n = 6). Each dot represents a gene. Genes considered to be significantly differentially expressed (adjusted p-value < 0.05) are depicted in turquoise. b Heatmap of differentially expressed genes (adjusted p-value < 0.05) between progressive MS and control CP. Samples are ordered by sample name. c 100% stacked chart for EPAS1 displaying the percentages of each splice variant in progressive MS and control CP. Samples are ordered by sample name. Splice variant IDs are the versions from Ensembl Human GRCh38 build 97 as of submission