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Table 1 Demographic data and diagnoses of patients

From: Histological correlates of postmortem ultra-high-resolution single-section MRI in cortical cerebral microinfarcts

Case

Age

Gender

Clinical Diagnosis

Cause of Death

Cortical Aβ Stage

CAA

NFT Staging (Gallyas/AT8)

PD Stage

Blocks used for screening

# MRI scanned sections/# MIs found

Location of Microinfarcts

1

84

F

Subacute cerebral MCA and PCA infarctions R

Pneumonia

0

0

2/3

0

Frontal, Hemipshere, Occipital b

2/2

Several in areas around the hemorrhage

2

76

M

Heart failure

Cardiac arrest

C

0

0/1

0

Frontal, Hemipshere, Occipital

2/1

Frontoparietal transition (post. Frontolateral.)

3

77

M

Subcortical SVD

Pulmonary embolism

0

0

0/1

0

Frontal, Hemipshere, Occipital

 

Ant. frontal lobe (inf.frontal)

4

72

M

Cerebral white matter microangiopathy

Unknown

0

0

2/3

0

Frontal, Hemipshere, Occipital

2/1

Parietooccipital

5

70

F

Subcortical SVD, arterial hypertension

Intracerebral bleeding in frontoparietal lobe

C

0

0/1

0

Frontal, Hemipshere, Occipital c

 

Middle parietal, post. Cingulate, sup. Temporal, occipital

6

83

M

Subcortical SVD, hydrocephalus

Aspiration pneumonia

B

0

2/3

0

Frontal, Hemipshere, Occipital

 

Frontal lobe (ant. Sup. frontal, middle frontal, inf. frontal)

7

69

M

Coronary artery sclerosis

Acute heart failure

B

0

1/3

0

Frontal, Hemipshere, Occipital

3/0

Frontal lobe (ant. Sup. frontal), occipital pole

8

89

F

Mixed dementia, arterial hypertension, subcortical SVD, TIA, Aneurysm of ACA, comp. CRF

Acute renal failure with bradycardiac arrhythmia

C, a

Lpm

4/5

0

Frontal, Hemipshere, Occipital

1/2

Ant. frontal, lat. Inf. parietal

9

84

F

Arterial hypertension

Ischemic left MCA infarction

C

Lpm

3/4

0

Frontal, Hemipshere, Occipital

 

Ant. sup. Frontal

10

74

F

Parkinson’s disease

Pulmonary embolism

B

0

2/3

4

Frontal, Hemipshere, Occipital

 

Hippocampus

  1. Alzheimer-related cortical Aβ deposits and neurofibrillary (NFT) changes were classified using the Braak staging (Acta Neuropathol 1991;82:239–59). Cortical and vascular Aβ deposits were visualized with the Campbell-Switzer silver stain and the anti-Aβ antibody 4G8. NFT staging was performed with the Gallyas silver stain and immunohistochemistry (IHC) with the anti-hyperphosphorylated tau antibody AT8. Parkinson staging was performed according to Braak (Neurobiol Aging 2003;24:197–211). ACA anterior cerebral artery, comp. CRF compensated chronic renal failure, Lpm leptomeningeal cerebral amyloid angiopathy (CAA), MIs Microinfarcts, SVD, small vessel disease, TIA transitory ischemic attack, aMajority of isocortical Aβ deposits diffuse. "One section was imaged twice. bCase with 13 blocks from the right and 16 blocks from left hemisphere; cCase with 10 blocks from right hemisphere