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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Histological correlates of postmortem ultra-high-resolution single-section MRI in cortical cerebral microinfarcts

Fig. 9

Thick brain section (case 8) first scanned with 11.7 T MRI and then double-labeled for Coll4 and UEA-l (a-j), whereas adjacent sections were stained with iron histochemistry (k; Prussian blue stain) and double-label immunohistochemistry for Coll4 and Aβ (l). a, f T2-weighted image does not show changes in the signal intensity in the microinfarct area (dotted arrow) despite the strong hyperintense signal produced by saline in a tear nearby and around the section. b, g The same microinfarct (dotted arrow) gave a hypointense T1-weighted signal. c, h In the PD-weighted image, the microinfarct gave a reduced and its margin a hyperintense proton signal. d-e and i-j The hypointense microinfarct zone with a blooming effect in the T2*-weighted image (d, i) contained a dense microvascular meshwork (e, j). k-l Microinfarct area giving a hypointense T2* signal (white arrows) showed iron deposition in the adjacent section (black arrows) independently from the diffuse Aβ deposition in superficial cortical layers, although larger iron aggregates in deep cortical layers (asterisk in k) may be localized in cored Aβ plaques (hashtag in l). ctx cortex; wm white matter. Scale bars: 2 mm (e), 500 μm (j) and 400 μm (k-l)

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