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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

Fig. 2

CA1 neurons in Tg mice show altered mitochondrial morphology. a Representative TEM images of CA1 sections from 6- and 12-mo Tg and Wt mice hippocampus (n = 3 for each mouse category). Mitochondria are highlighted by transparent colored overlay. The scale bars represent 5 μm or 1 μm. b Illustration of the quantification of mitochondrial area from TEM images. c Graph shows the mean of mitochondrial area per mouse category (mitochondria: 6-mo-Wt n = 63; 6-mo-Tg n = 51; 12-mo-Wt n = 72; and 12-mo Tg n = 54). Data is presented as mean ± SEM (*P = 0.039; **P = 0.0077). d WB analysis of extracts from 6-mo Wt and Tg mice CA1 (WT, n = 6; Tg, n = 7), using antibodies against mitochondrial fission and fusion proteins: DRP1, pDRP1 (S616) and OPA1. Actin was used as loading control. e WB analysis of extracts from 12-mo Wt and Tg mice hippocampi (Wt, n = 5; Tg, n = 5). Actin or Vinculin were used as loading control. Quantifications are shown in graphs. Data is presented as mean ± SEM (*P < 0.05; **P < 0.01). f WB analysis of extracts from 6-mo Wt and Tg mice CA1 (Wt, n = 6; Tg, n = 6) using an antibody cocktail against selected OXPHOS assembly subunits (CI: NDUFB8; CII: SDHB; CIII, MTCO1; CIV: UQCRC2; CV: ATP5A). g Graph showing the quantification results normalized to GAPDH. Data are shown as mean ± SEM (*P < 0.05)

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