Fig. 1

CA1 neurons in 6-mo Tg mice are enriched with tau oligomers. a Schematic of tau pathology progression in CA1 neurons of THY-Tau22 mice. b Representative images of sagittal CA1 sections from 6- and 12-mo Tg and Wt mice hippocampus (n = 3 for each mouse category). The sections were labeled with antibodies against pathological phospho-tau (pThr212), and tau oligomers (TOC1), respectively. The sections were analyzed by laser scanning confocal microscopy (z projection). Nuclei were visualized by DAPI staining. The scale bars represent 20 μm