Fig. 8

N-acetylcysteine reduces hypoxia-ischemia brain injury in P3C-sensitized neonatal rats. Neonatal rats were treated with P3C or P3C + NAC 14 h before being exposed to hypoxia-ischemia. One week later, mice were sacrificed and MAP 2-immunopositive area (neurons) was measured on three brain sections obtained at 3 different levels (represented in lower panels, Bregma − 3.4 to − 2.4). Results are expressed as a percentage of signal loss as compared to the contralateral uninjured hemisphere. Individual data and mean ± SEM are shown for the three levels L1, L2, and L3 (n = 25 and 24 for P3C- and P3C + NAC-treated rats, respectively). P values were calculated by Mann-Whitney non-parametric test