From: DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations
CNS Region
8-OHdG Concentration (pg/μl, mean ± SD)
Control
ALS
Motor Cortex
24 ± 11
35 ± 15*
Somatosensory Cortex
32 ± 14
29 ± 12
Spinal Cord-ventral horn
17 ± 7
27 ± 13*
Spinal Cord-dorsal horn
15 ± 11
18 ± 10