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Table 6 8-OHdG Levels in Human Control and ALS CNS Regionsa

From: DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

CNS Region

8-OHdG Concentration (pg/μl, mean ± SD)

Control

ALS

Motor Cortex

24 ± 11

35 ± 15*

Somatosensory Cortex

32 ± 14

29 ± 12

Spinal Cord-ventral horn

17 ± 7

27 ± 13*

Spinal Cord-dorsal horn

15 ± 11

18 ± 10

  1. a8-OHdG levels were measured by ELISA. Tissue samples were obtained
  2. by careful anatomical micropunch technique
  3. *p < 0.05