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Table 5 Summary of Off-Target Analysisa

From: DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

ID

Sequence

Mismatch

Score

Chromosome position

Mutation

OT1

CAAAATTCAATAGACACATGGG -- hit

GAATCTTCAATAGACACATNGG – query

3

0.53

Chr15:25520090-25,520,111

Not detected

OT2

GTATATTCCATAGACACATGGG -- hit

GAATCTTCAATAGACACATNGG – query

3

0.86

Chr4:109681139-109,681,160

Not detected

OT3

TCATCTTCAAAAGACACATTGG -- hit

GAATCTTCAATAGACACATNGG – query

3

1.08

Chr13:46227046-46,227,067

Not detected

OT4

GTATCTTGAAAAGACACATGGG -- hit

GAATCTTCAATAGACACATNGG – query

3

1.3

Chr11:87945053-87,945,074

Not detected

OT5

GATTCTACAATGGACACATTGG -- hit

GAATCTTCAATAGACACATNGG – query

3

1.54

Chr12:24874767-24,874,788

Not detected

OT6

GAATTTCCAATGGACACATTGG -- hit

GAATCTTCAATAGACACATNGG – query

3

1.58

Chr7:134494940-134,494,961

Not detected

OT7

AAATCTTTAATACACACATCGG -- hit

GAATCTTCAATAGACACATNGG – query

3

1.78

Chr4:107649971-107,649,992

Not detected

  1. aMismatched bases are in bold