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Table 1 Human Autopsy Cases Used for Brain and Spinal Cord Samples

From: DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

Group

Case Number

Age (years)/Sex

Postmortem Delay (hours)

Cause of Death

Controls (Neurological Disease Free)

487

73/male

22

Pancreatic cancer

515

62/male

21

Aortic aneurysm

712

44/female

20

Pneumonia

719

66/male

10

Myocardial infarction

961

59/female

6

Myocardial infarction

993

66/male

12

Prostatic carcinoma

1277

80/female

8

Lymphoma

1344

53/male

12

Metastatic carcinoma

1348

44/male

18

Lymphoma

1361

49/female

15

Thromboembolic disease

1517

71/female

16

Heart disease

1591

94/male

16

Pneumonia

1603

89/male

16

Pulmonary embolism

1613

74/male

4

Myocardial infarction

1683

91/female

8

Cardiomyopathy

ALS

345

59/female

3

Respiratory arrest

414

65/male

4

Respiratory arrest

433

71/male

17

Respiratory arrest

447

69/female

15

Respiratory arrest

492

68/female

18

Respiratory arrest

834F

46/male

3

Respiratory arrest

875

70/female

24

Respiratory arrest

950F

38/male

22

Respiratory arrest

1014

72/male

5

Respiratory arrest

1088

66/male

7

Respiratory arrest

1108

64/female

8

Respiratory arrest

1151

57/female

14

Respiratory arrest

1161

47/male

6

Pneumonia

1169

67/female

15

Respiratory arrest

1176F

27/male

6

Respiratory arrest

1359

61/female

14

Respiratory arrest

1365

59/male

7

Respiratory arrest

1386

69/female

15

Pneumonia

1413

79/male

10

Respiratory arrest

1452

65/female

6

Respiratory arrest

1453

60/male

22

Pneumonia

1485

61/female

5

Pneumonia

1589

55/male

10

Pneumonia

1614

69/male

18

Respiratory arrest

1620

63/male

10

Respiratory arrest

1623

71/female

59

Cardiopulmonary arrest

1629

55/female

12

Pneumonia

1635

68/female

5

Respiratory arrest

1668

76/male

7

Respiratory arrest

1693F

42/male

6

Respiratory arrest

1713

54/female

14

Respiratory arrest

1742

55/male

5

Pneumonia

1755

72/female

5

Respiratory arrest

1789F-SOD1A4V

55/male

14

Respiratory arrest